Animal Rights

Scientists Use Pigs Instead of Embryonic Stem Cells to "Avoid the Controversy"

Published July 06, 2009 @ 06:39AM PT

This university newspaper article about experimentation at the University of Missouri's animal research labs in Columbia says much about how little thought people give to researching on animals--and to the fact that there are ethical issues with forcibly taking another conscious, sentient, living being and turning him or her into an unwilling test subject. The article begins,

Stem cell research has been considered by some to be the next area in science that could potentially produce life-saving cures, but controversy over the issue has limited research opportunities.

An MU researcher thinks he has found a way to avoid the controversy altogether.

And this "noncontroversial" solution, of course, is to use pigs and their connective tissue to try to create cells that "think" they're embryonic stem cells.

Induced stem cells have many advantages over cells taken from embryos, Roberts said. For one, they allow researchers to avoid the controversial procedures utilized in the gathering of embryonic stem cells, he said; the method for creating induced stem cells does not involve cloning and does not utilize embryos.

It is "controversial" to use human embryonic stem cells for which no living, sentient being is harmed because of some people's extreme religious views, but completely without controversy to replace experimentation on those cells with experimentation on a live animal?

But Goldstein said there are still risks involved in induced stem cells and that it remains unclear how effective these new stem cells can be.

"The problem is that these reprogrammed cells do have risks of cancer that are different than the kinds of risks for cancer with embryonic stem cells," Goldstein said. "And we are still trying to understand what the relevant issues are."

Goldstein said that though induced stem cells have many desirable properties, it is not yet known how similar they are to stem cells derived from embryos and whether they will turn out to be identical in their ability to be used in therapeutic approaches.

So as is usual with research on animals, essentially we don't have a clue whether there's any point to this research, whether this will yield any usable, relevant, trustworthy results for human purposes. But we'll do it anyway. We'll screw around with these cells, insert them back into the pigs to see if that can possibly be done "without causing any medical problems in the animals," and pretend like all this is going to produce reliable results for humans.

Because embryos have some bizarre semblance of rights. But a thinking, emotional, personality-filled animal, who can be harmed and has an interest in not being harmed, doesn't.

Science Daily also quotes Roberts as saying, "Cures with stem cells are not right around the corner, but the pig could be an excellent model for testing new therapies because it is so similar to humans in many ways."

For what I think about that argument (the ways in which we're similar versus the ways in which we're different and the implications of those similarities and differences), see this related post: "Farm Animals, on the Plate and in the Lab, and Human Hypocrisy." It concludes much the way I'm inclined to conclude this one.

Photo by Jeremy Portje/Associated Press

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Comments (25)

  1. Philosophia and Animal Liberation

    Some scientists really embarass the scientific community. It's like s/he didn't even think about the nonhuman side of the controversy and barely brushed over the fact that these cells will be markedly poor models in comparison to human stem cells... aside from the fact that no being has to suffer for them.

     

    Posted by Philosophia and Animal Liberation on 07/06/2009 @ 07:48AM PT

  2. Lisa Smolen

    Scary there is more sentiment attached to non-sentient clusters of cells than to a creature you can look in the eye and see the suffering directly.

    Posted by Lisa Smolen on 07/06/2009 @ 07:52AM PT

  3. Kelly Garbato

    Well said.

    Posted by Kelly Garbato on 07/06/2009 @ 07:57AM PT

  4. Reply to thread
  5. sarah karp

    Any thoughts on the use of pig-valves in human hearts to great effect, and the research used in that case to the benefit of many human lives (at the cost of the pigs' lives, of course)?

    I don't have time to run down any papers on this right now, perhaps later today... but from the AR POV, how do ya'll feel about it?

    Posted by sarah karp on 07/06/2009 @ 08:39AM PT

  6. Philosophia and Animal Liberation

    Artificial valves that don't come from nonhuman animals are more effective and last much longer. That's from the logic POV, it just so happens to support the AR one, too :-)

    Posted by Philosophia and Animal Liberation on 07/07/2009 @ 11:45AM PT

  7. Reply to thread
  8. Cerberus  III

    Sarah, your comment makes the assumption, an arrogant and ignorant one, I believe, and one that mankind makes constantly: that animal are less important than humans, 'second-class citizens of the planet, if you will, and that their needs are secondary to those of humans.

    It is ignorant because we have no way of knowing whether that is objectively true. We have mistaken 'being Top of the Food Chain' for 'being The Reason Why Existence Exists', and that everything is subjugated to that Reason, including the animals (the environment has already spoken on this issue)

    Whether one has secular or religious reasons for making the above assumption, it is unjustifiable on any ground unless you are willing to invoke the "Might is Right" mode of value, in which case you invite anarchy and immorality in any scenario where there are ethical considerations.

    Posted by Cerberus III on 07/06/2009 @ 11:23PM PT

  9. sarah karp

    Actually, there was no assumption made in my comment, as I was merely stating a fact (pig-valves are used in weakened human hearts to great effect) and asking for your thoughts on the matter without any judgement, implied or explicit. 

    I was going off the tone of the above articles, which seem to report that without exception, experimentation is done without any real end in mind. While I agree that many university-level projects are disgusting money-makers and resume boosters for people without an interest in furthering real, beneficial science, I am offering an example wherein a specific goal was set and reached, and in which there was undoubtedly an amount of suffering that alleviated another being's suffering. Do you feel that there is any value in that?

    Anyway, I'll take what you say to mean the following:

    Using any species (other than humans) for the good of (another species) is immoral, arrogant, and ignorant and should not be done under any circumstance, including to save the lives of members of another species.

    I'd point out that the "Might is Right" argument is precisely what is used in defense of animals and their rights. Because of the specific food-chain heirarchy, our civilization is coming to realize a responsibility of stewardship over those who cannot defend themselves. Our 'might' to defend all 'rights,' if you will. It is a two-sided argument, with defenses based in religion and in modern secularism. This does not invite anarchy, but rather calls for compassion for those 'second-class citizens' and for the weak, elderly, infirm, impressionable, or otherwise presented with opportunitites that are not given by birth of modernity to healthy homo-sapien males of European descent. Science is growing and acknowledging these things as society advances.

    If a human consents to give another human a needed kidney, no one questions that. Both beings indeed feel pain through the process, but wind up healthy and functional in the end. But if a viable kidney is not available from a human, and is instead taken by force from an unconsenting ape, say, and both beings feel pain, but wind up healthy and functional in the end, the ethical concern is over the nonconsent of the ape. However, if the human were to die without that kidney, given without consent, the ethical concern is to whom compassion should be allowed. Is the infirm human less pitiable, because of his supposed place on the food chain (now lost because of his illness) than the unconsenting but healthy ape? If they are to be treated with equality, as the animal rights position is, how can it be justifiable that the human is left to die painfully, when a viable non-fatal solution is available from the ape?

    It is not a black-and-white argument, as your comment seems to indicate. Given scientific and moral advances in society, we've discovered a lot of gray between right and wrong.

     

    Posted by sarah karp on 07/07/2009 @ 07:07AM PT

  10. Stephanie Ernst

    I do agree that your original question was misconstrued here, Sarah, but I do also agree with what you assumed to be the answer: that, yes, animal rights advocates would take the position that it's inherently unethical to use, inflict suffering on, and kill an animal even when the benefit to humans is clear.

    With regard to your ape-kidney scenario--would it be acceptable and ethical to force a human whose cognitive abilities match that of a nonhuman primate's or a pig's to supply a kidney without consent? A person living in a nursing home? A noncommunicative person? A person in a coma? If it would not be acceptable to force these individuals into an inherently risky surgery for the benefit of someone else--if it would not be acceptable to treat them as merely organ resources--then why would it be acceptable to treat nonhumans whose abilities, personalities, capacity for suffering, and self-awareness are equal to, or in some cases even greater than, these individuals'?

    If we were truly treating humans and apes "with equality," as you say, and we felt like we had a right and duty to take an organ from a fellow animal without that animal's consent, our solution wouldn't be to take one from a nonhuman ape--it would be to take one from a fellow human, someone who would be a far more exact match.

    In this hypothetical, if forcibly taking an organ from a disadvantaged human wouldn't be acceptable, forcibly taking one from a nonhuman wouldn't be ethical either.

    Posted by Stephanie Ernst on 07/07/2009 @ 07:26AM PT

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  11. R.L. Tokyo

    Stephanie/Cerberus - just so we're clear: if an organ from an animal (heart valve/kidney/whatever) were the only thing that was capable of saving your life, you would turn it down?

    Posted by R.L. Tokyo on 07/07/2009 @ 08:14AM PT

  12. Jen Ruff

    @R.L: I can't speak for anyone else, but let me ask you a question: if the only thing that could save your life was a black market kidney (illegally obtained by force), would you choose to take it? I think a lot of people would - and that would be an organ from a human animal, obtained by force, without permission.

     

    What you (R.L) may not be understanding is that many members of the AR community truly do see non-human animals in a very different way from the way other humans do. I have undergone a Gestalt shift in my views on non-human animals. It's hard to understand for many people, but suffice to say, I would feel the same about taking a kidney from a non-human animal as I would about taking the black market kidney obtained by force from a human animal. Would I do it in either case? I doubt it, but I don't know. I would like to say no, but I hope I'll never, ever reach that point. 

    Posted by Jen Ruff on 07/07/2009 @ 09:40AM PT

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  13. sarah karp

    Yes, taking an organ from a human match would be the (obvious) best solution.

    However, you wouldn't use an organ from an elderly person in a nursing home on an infant, nor would you use one from anyone with the potential to eventually communicate their consent or nonconsent (the person in a coma). You want as close a match as possible. For example: If an human infant is dying and there is no immediately matchable human organ to help him/her, the case is in fact that the infant has no more the capacity to accept the tissue than does the animal that gives it.

    Better than R.L.'s question (because it speaks to our ability as humans to assist/defend those who cannot do so for themselves, and how we prioritize life):

    If your child was dying, and the only thing capable of saving his/her life was tissue from an animal, how would that effect your decision?

    Posted by sarah karp on 07/07/2009 @ 09:52AM PT

  14. Stephanie Ernst

    This and another thread both today are fast becoming tangential "gotcha" threads where non-AR folks keep trying to present new hypothetical scenarios to challenge or "catch" AR advocates. I ask that we try to find a way to return to the specific issues presented in this post or end the subthread. And please remember that regardless of the direction some took this thread, the reality is that most animal research/use does not have the clear (or in many cases any) potential to reliably help humans.

    This is not a forum for discussion of vivisection in general, but there are indeed websites with such forums out there, and they would be the appropriate place to have this conversation.

    For the record, Sarah, I wasn't referring to the elderly in nursing homes. I was referring to those with permanent or irreversible disabilities or impairments--as I said, people who may have the same or even less cognitive abilities than the animals you propose we forcibly take organs from. Neither situation is ethical.

    Posted by Stephanie Ernst on 07/07/2009 @ 10:19AM PT

  15. R.L. Tokyo

    Sorry, don't mind me, I was just curious.

    Posted by R.L. Tokyo on 07/07/2009 @ 10:25AM PT

  16. Stephanie Ernst

    No need for apologies, from anyone. I just wanted to redirect this before it went any further. Thanks for understanding.

    Posted by Stephanie Ernst on 07/07/2009 @ 10:42AM PT

  17. Philosophia and Animal Liberation

    Xenotransplantation should also be addressed as something that NEVER works from nonhuman animal to human. EVERYONE that has had a xenotransplanted organ has died. Some scientists will claim a success on one or two because the person lived 72 hours after the transplant.

    On top of that, xenotransplantation opens the door for extreme disease and bacteria mutations across species (you know, like how aids came about). There are things in a pig's bloodstream that are toxic to humans and vice versa.

    Xenotransplantation is not the answer and never will be. Organ donation, prevention, and so on are the solutions.

    Posted by Philosophia and Animal Liberation on 07/07/2009 @ 11:48AM PT

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  18. Alex Melonas

    Sarah,

    Your use of "might-makes-right" isn't intelligible.

    The concept is derived from the proposition that the ability to do something -- or "can" -- determines the ought -- or "right." Your use of it merely illuminates how the "can" is useful for implementing the ought; however, the ought or "right" doesn't follow from the ability to do something, it is independently determined.  

    Sarah and R.L.,

    Your questions are quite beside the point. Whatever I would do under X and Y extreme circumstances doesn't answer the question: Is the argument for "animal rights" valid?

    My biased or personal-oriented decision in the matter of killing ten strangers to save my mother, for example, or killing ten strangers to save my beloved dog, doesn't negate nor prove the argument for "animal rights" (or for "human rights"). It simply gets at some flaw (perhaps?) of my own.

    In the end, these are definitionally "gotcha questions" that are without any real reasoned merit.  

    Posted by Alex Melonas on 07/07/2009 @ 03:19PM PT

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  19. Stephanie Ernst

    Please let this go--on both sides--so that it doesn't spiral out of control, as we all know it easily could. I can't ask one participant or set of participants in a tangential thread to stop posting if the other side is going to keep responding. I definitely appreciate the points that have been made since I made the request, particularly about xenotransplantation, but I'd still like to repeat the request at this point.

    Posted by Stephanie Ernst on 07/07/2009 @ 03:26PM PT

  20. sarah karp

    I'm not going to argue any further, I'm sick of the conversation myself. I want to thank you all for your responses to my initial query, particularly Jen and Stephanie.

    I am not trying to 'get' anyone to rescind their  fundamental beliefs, only to question them, because I believe it is a challenging and useful exercise to fully examine all the implications of these very strongly held worldviews. Bringing the process out into this forum can help others really understand where it all comes from and perhaps encourage them to see that AR Advocates aren't the 'nutjobs' they are frequently accused of being.

    Neither do I consider myself one of these "non-AR folk." I may fall more in the animal welfare camp for now, but that's why I (and many others) read this blog and participate in the conversation. We are examining our own perspectives and those of similar (if not exactly the same) ilk, to find weaknesses and strengths in both and to reconcile our (sometimes admittedly implausible) ideas with reality.

    Thanks for allowing our participation.

    Posted by sarah karp on 07/08/2009 @ 06:44AM PT

  21. Reply to thread
  22. Bea Elliott

    If I can expound on Lisa's comment: "Scary there is more sentiment attached to non-sentient clusters of cells than to a creature you can look in the eye and see the suffering directly."

    Here is the hypothetical: A group of people are stranded in sub-zero desolation and with absolutely no means of survival... one in the group has died of starvation. Members can opt to kill a nonhuman animal for survival, or consume the human corpse... Which choice will be met with more controversy once the group is rescued?

    I'm certain leaving the (dead) human remains "in tact", and slaying the living beast will be met with approval. And the other with disdain. This scenario speaks volumes of our speciesism. 

    As long as we are a culture that reveres human supremacy, including the "potential" of human life -- we can't expect science to adjust to any ethical (or productive) position either. 

    Posted by Bea Elliott on 07/07/2009 @ 08:33AM PT

  23. Michele McCowan

    Bea,

    Just wondering if you are speaking of the 1972 Andes plane crash, where the survivors resorted to cannibalism in order to survive? Or just a scenario?

    FYI, there is another documentary just recently released that poses the same question. Have you seen the film? It's called "Stranded: I've Come from a Plane That Crashed on the Mountains"

    In the Andes crash of 1972, the people who chose not to eat their friends wound up starving and freezing to death, only to become the next meals of the survivors. I don't think they had the choice of killing another type of animal, but some were willing to eat human flesh in order to survive. The others...didn't survive and could not tell their story.

    It's a tough question to deal with, hypothetical or not. I think that if they would eat a dead human, they would easily take another animal's life to survive...easily. They, at least, did not have to make the decision to kill the human. They already had one to start with, and the rest came in time.

     

    Posted by Michele McCowan on 07/07/2009 @ 08:53PM PT

  24. Bea Elliott

    Hi Michele... Yes, I am referring to the story about the Andes plan crash.  I read the book 30+ years ago - and it stuck in my mind since.  A desperate situation for them to choose cannibalism for survival... Many did (what I consider) the right thing and lived to tell it all.  No, I haven't seen "Stranded" yet...

    I wasn't questioning whether someone in that position would kill an animal - of course they would if it meant survival.

    My point though... was to illustrate that the killing of a living being (a nonhuman) would have been more socially acceptable than consuming the (dead) remains of a person.  If one were left with only one option - to preserve their life... I'm sure many would choose to kill (a nonhuman) rather than eat (human) flesh. 

    The thought is so repugnant to most... Yet, we readily eat our cousin's "wings", "breasts" and babies... This dissonance really puts the spotlight on our speciesism...

    Posted by Bea Elliott on 07/07/2009 @ 10:47PM PT

  25. Alex Melonas

    Bea's question is simple, rationally, just as the original post displays our species' simple irrationality.

    We all accept the proposition that causing harm is of moral concern and yet our prejudice against nonhuman animals, which is as rationally indefensible as any other mere "out-grouping" mechanism, acts as an alternative proposition that stifles the logical and consistent application of the original proposition. 

    Throughout the history of moral thought, we see this happening constantly; the alternative propositions, however, concerned "sub-sets" of the human animal population.

    Per the original post, we have a cluster of non-sentient cells that by definition have no interests versus a fully sentient nonhuman animal who by definition has interests: the outcome, rationally, is self-evident. As a matter of logic, it would be like arguing that an inanimate object ought to trump, morally, a conscious being.

    Unless we assume something that cannot (by definition) be rationally defended (i.e., "ensoulment"), which we shouldn't do because again we all accept the proposition that causing harm is bad, impartially speaking, (What does possessing a soul have to do, logically, with the badness of suffering?) the "solution" to this controversial problem, as the cited article puts it, is logically and morally absurd.  

    Posted by Alex Melonas on 07/08/2009 @ 07:14AM PT

  26. Stuart Chaifetz

    It's important to understand how doomed to failure these experiments are, because of the incompatibility of different species.

    Take a look at this paper I wrote on how, when they tried to create hybrid human/animal embryos, which were 99.9% human, that they still failed:  http://www.askuswhy.com/hybrid.html

    Stu

    Posted by Stuart Chaifetz on 07/08/2009 @ 08:00AM PT

  27. David R.

    I think this article points out one of the most tragic examples of speciesism.  We refuse to use non-sentient cells in research, simply because they are human.  But we would experiment on a living, thinking, feeling being instead, and justify by saying "It's not human."  

    To people who oppose stem cell research but insist than animal testing saves lives, I would say that stem cell research causes no pain or suffering.  It only offends "human dignity," and I really don't see what we have to be dignified about.

    Posted by David R. on 07/09/2009 @ 09:26AM PT

  28. Per:nce Daily also quotes Roberts as saying, "Cures with stem cells are not right around the corner, but the pig could be an excellent model for testing new therapies because it is so similar to humans in many ways."

    He should enthusiastically cut to the chase and put himself up for a model and similar can be exact.

    Posted by Jade Golden on 08/21/2009 @ 12:31PM PT

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Stephanie Ernst

Stephanie is an independent animal rights advocate, a vegan, a tree-hugging environmentalist, and a freelance editor and writer. She lives in St. Louis with an aging corgi-lab and an adolescent rescued pit bull.

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